What we're working on
The lab works in five areas. They are connected: clinical data raises mechanical questions, biomechanical models inform new techniques, those techniques generate new data, and the lab's own software moves the work along. Each area is described below with representative studies, followed by the open problems we are actively working on.
Population-scale evidence
METHODSFederated EHR analysis
Pharmacoepidemiology
Causal inference
Survival modeling
Randomized trials answer one question at a time and take years. Modern electronic health record networks hold the records of tens of millions of patients, enough to screen entire classes of exposure against a disease in a single, carefully controlled analysis. We build those analyses for musculoskeletal disease.
The work is methodological as much as clinical: controlling confounding by indication, handling immortal-time and selection bias, and making federated estimates that hold up across institutions. Done well, it turns routine care data into hypotheses worth testing and, sometimes, into answers.
Computational biomechanics
METHODSFinite element analysis
Patient-specific modeling
Image-based meshing
Constitutive modeling
Some questions are mechanical and cannot be answered by any trial: how a surgical construct shares load, where it concentrates stress, and where it will fail first. We build patient-specific finite element models from clinical imaging to answer them, then tie the predictions back to real outcomes.
Our current focus is the hip abductors. Tendon repairs fail often, and augmentation with a scaffold is increasingly common without a clear mechanical rationale. We model exactly how a scaffold redistributes load across the repair, patient by patient, to understand who benefits and why.
Robotics and intraoperative data
METHODSRobotic arthroplasty data
Prediction vs ground truth
Computer vision
Registry linkage
Robotic platforms for joint replacement record every cut, gap, and alignment angle, an unusually rich, structured stream of intraoperative data. Most of it is never analyzed. We treat the robot's plan as a prediction and test it against what the surgeon actually finds and does.
The first results are already pointing somewhere useful: as a patient's native coronal deformity increases, the platform systematically underpredicts the medial gap, with direct implications for how the knee is balanced. That is the kind of quiet, measurable gap between model and reality that this program exists to close.
AI agents in the clinical workflow
METHODSLLM & agent engineering
Retrieval & evidence synthesis
FHIR / clinical data
Evaluation & safety
The lab runs on software it builds. We design agentic systems to do real work in a surgical department: synthesizing evidence, assembling cohorts from messy clinical data, and drafting structured documentation. Because they operate where care happens, we hold them to a clinical standard, evaluated, audited, and measured against the task they claim to do.
This is the through-line of the whole lab. The same agents that accelerate a literature review or a database build are prototypes for tools that could one day sit inside the clinical workflow itself. We are interested in both: the research accelerant and the eventual product.
Surgical technique innovation
METHODSSurgical anatomy
Approach & construct design
Cadaveric & clinical validation
Outcome measurement
New evidence and new mechanics are only worth as much as what reaches the operating room. This program takes anatomic and biomechanical insight all the way to technique: new approaches, instruments, and repair strategies, then measures whether they actually help.
Recent work includes a novel superior approach to total hip arthroplasty and a re-examination of how partial, concealed abductor tears are classified, an under-recognized lesion that standard descriptions miss. The aim is a technique that changes practice, supported by data.
Where the work is headed
Predicting which abductor tendon repairs fail
Gluteus medius repairs fail at meaningful rates, and outcomes vary widely. Using imaging, intraoperative findings, and longitudinal outcomes from our repair cohort, the goal is a model that identifies repairs at high risk of failure and the factors that drive it.
DATA: IMAGING, OPERATIVE, OUTCOMES · METHODS: ML, SURVIVAL ANALYSISFrom intraoperative data to a structured operative record
Robotic platforms log detailed data for every case, but little of it reaches surgical registries because the translation is manual. The problem is an agentic pipeline that converts intraoperative and EHR data into structured, auditable documentation a surgeon would sign.
DATA: ROBOTIC LOGS, EHR · METHODS: LLM AGENTS, FHIRSeparating cause from association in drug-osteoarthritis screens
A medication-wide screen surfaces many drugs associated with osteoarthritis. Association is not cause. The work is to take the strongest signals and test them with negative controls, target-trial emulation, and sensitivity analysis to see what holds.
DATA: FEDERATED EHR · METHODS: CAUSAL INFERENCE, PHARMACOEPIDEMIOLOGYA fast surrogate for patient-specific finite element analysis
A full finite element model of a repair construct takes hours to build and solve. A learned surrogate that predicts the stress field from imaging in seconds, accurately enough to inform a decision, would make this usable in clinic.
DATA: IMAGING, FE MODELS · METHODS: SURROGATE MODELING, GEOMETRY PROCESSINGCorrecting the robot's gap prediction across deformity
Robotic knee replacement underpredicts the medial gap as native coronal deformity increases. The problem is to characterize that error across the full deformity range and build a correction a surgeon can use intraoperatively.
DATA: ROBOTIC ARTHROPLASTY · METHODS: MODELING, DATA SCIENCEA reproducible classification for concealed abductor tears
Partial, subsurface abductor tears sit under intact superficial fibers and are described in the literature under competing names. The work is an imaging-based, reproducible classification, ideally with automated segmentation, that the field can use consistently.
DATA: MRI · METHODS: SEGMENTATION, CLINICAL RESEARCHIf one of these is close to what you do, see how to join.